高主导频率和分断潜力在AF期间不表明焦点或旋转激活
Lianne N van Staveren1, Richard C Hendriks2, Yannick J H J Taverne3
1Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
JACC. Clinical electrophysiology
|July 26, 2023
概括
主导频率 (DFs) 和复杂的分成型心房电图 (CFAEs) 不总是与焦点或旋转激活模式相关联. 这些发现挑战了目前针对这些部位进行心房动 (AF) 移除的方法.
科学领域:
- 电子生理学 电子生理学
- 心脏节律失常症 心脏节律失常症
- 医疗器械技术 医疗器械技术
背景情况:
- 主导频率 (DFs) 和复杂分成型心房电图 (CFAEs) 在心房动 (AF) 废除目标识别中得到利用.
- 对于DF,CFAE和潜在的激活模式之间的准确关系仍然不完全理解.
研究的目的:
- 阐明激活模式和在AF期间展现DF和CFAE的地点之间的关系.
- 根据DF和CFAE评估目前确定AF消去目标的标准的有效性.
主要方法:
- 在71名参与者中进行了高分辨率的上心脏映射,覆盖了右心房和左心房.
- 激活模式被分类,并确定主导频率 (DFmax) 和复杂分成型心房电图 (CFAEmax) 位点.
- 统计分析调查了激活模式,DFmax和潜在类型之间的关联.
主要成果:
- 主要位于左心室槽的DFmax位点显示出更平滑的传播和更少的导电阻塞,单个电位的比例更高,分数电位更少.
- 主要在肺静脉区域的CFAEmax位点表现出不太顺的传播和更多的残留活动,主要具有分成的潜力.
- 无论是DFmax还是CFAEmax站点都没有始终证明焦点或旋转激活模式.
结论:
- 该研究发现DFmax或CFAEmax位点与焦点或旋转激活模式之间没有一致的关联.
- 目前针对AF剥离的DFmax和CFAEmax位点的目标标准可能无法通过观察到的激活动态得到充分支持.
- 需要进一步的研究,以完善在AF中识别有效的废除目标的策略.
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