与代谢功能障碍相关的脂肪肝疾病对心血管的影响
Zhewen Ren1, Anke Wesselius2, Coen D A Stehouwer3
1Division of Endocrinology and Metabolic Disease, Department of Internal Medicine, Maastricht University Medical Center, P Debyelaan 25, 6229 HX Maastricht, the Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands; Laboratory for Metabolism and Vascular Medicine, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands.
非酒精性脂肪肝 (NAFLD) 和与代谢功能障碍相关的脂肪肝 (MAFLD) 会增加心血管疾病 (CVD) 的风险. 本综述提供了将NAFLD/MAFLD整合到心脏病风险评估和预防管理中的工具.
科学领域:
- 肝病学和心脏病学.
- 代谢疾病 代谢疾病
- 临床风险预测预测
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 和与代谢功能障碍相关的脂肪性肝病 (MAFLD) 与心血管疾病 (CVD) 有关.
- 有证据表明NAFLD/MAFLD和心血管疾病之间存在因果关系,这得到了孟德尔随机化研究的支持.
- 目前的指导方针建议在NAFLD/MAFLD患者中管理心血管风险因素.
研究的目的:
- 审查NAFLD/MAFLD与发生心血管疾病之间的关联.
- 讨论将NAFLD/MAFLD纳入心血管风险评分中的挑战.
- 建议在NAFLD/MAFLD患者中预防心血管疾病的实用工具和研究方向.
主要方法:
- 对调查NAFLD/MAFLD和CVD的研究进行文献综述.
- 对孟德尔随机化研究的分析,推断因果关系.
- 综合当前的指南和临床建议.
主要成果:
- NAFLD和MAFLD独立地与心血管疾病风险增加有关.
- 遗传证据支持NAFLD/MAFLD和心血管疾病之间的因果关系.
- 对NAFLD/MAFLD在心脏病风险评分中的最佳整合尚不清楚.
结论:
- NAFLD/MAFLD代表了心血管疾病的重大风险因素.
- 需要进一步的研究来完善NAFLD/MAFLD患者心血管疾病风险分层.
- 需要实用策略来改善这种人群中的心血管疾病事件预防.
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