与代谢相关的脂肪肝疾病的管理
Kirthika Venkatesan1, Nisha Nigil Haroon2
1Caribbean Medical University School of Medicine, 25 Pater Euwensweg, Willemstad, Curaçao; Walden University, 650 South Exerter Street, Baltimore, MD 21202, USA.
Endocrinology and metabolism clinics of North America
|July 26, 2023
概括
代谢相关脂肪肝 (MAFLD) 是一种常见的肝脏疾病,影响全球超过30%的人口. 由于缺乏批准的药物,目前的管理层强调生活方式的改变.
科学领域:
- 肝病学和胃肠道学
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 公共卫生
背景情况:
- 代谢相关的脂肪肝病 (MAFLD),以前的非酒精性脂肪肝病 (NAFLD),是全球慢性肝病的主要原因.
- 患病率超过30%,与肥胖和相关疾病相关的患病率不断增加.
- MAFLD是肝移植的重要和日益增长的指示.
研究的目的:
- 总结目前对代谢相关脂肪肝疾病 (MAFLD) 的理解.
- 突出MAFLD的风险因素,肝外并发症和管理策略.
主要方法:
- 文献综述和现有流行病学数据的综合.
- 风险因素的分析,包括生活方式,遗传学和肠道微生物群.
- 检查相关的肝外疾病和当前的治疗模式.
主要成果:
- MAFLD是全球最常见的肝病,影响超过30%的个人.
- 关键的危险因素包括不良的生活方式,遗传倾向,晚年,男性性别和肠道疾病.
- 相关疾病包括心血管疾病,功能障碍和结直肠癌.
结论:
- MAFLD代表着一个重要的全球健康负担,其患病率越来越高.
- 由于缺乏特定的药物治疗方法,有效的管理目前依赖于生活方式的改变.
- 鉴于疾病的复杂性和相关并发症,对向治疗的进一步研究是有必要的.
相关概念视频
Chronic Pancreatitis II: Collaborative Care
113
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
113
Overview of Lipid Metabolism
1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
Overview of Fatty Acid Metabolism
30.8K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.8K
Acute Pancreatitis II: Clinical Manifestations and Management
150
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
150
Diabetes: Management and Pharmacotherapy
317
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
317
Cystic Fibrosis: Management
194
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
194


