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在疑似喘患者间接支气管挑战后,呼出的挥发性有机化合物的变化
Adam Peel1, Ran Wang2,3, Waqar Ahmed2
1Respiratory medicine, Norfolk Community Health and Care NHS Trust, Norwich, Norfolk, UK.
Thorax
|July 26, 2023
概括
在喘患者中,吸入曼尼托尔挑战改变了呼出的挥发性有机化合物 (VOC). 支气管过敏反应 (BHR) 患者的明显的VOC概况表明潜在的喘生物标志物.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 生物标志物发现发现
- 临床诊断 临床诊断 临床诊断
背景情况:
- 吸入的曼尼托尔通过炎症细胞介质诱导支气管收缩.
- 曼尼托尔挑战作为喘的诊断工具和急性发作的模型.
- 这项研究探讨了曼尼托尔对呼出的挥发性有机化合物 (VOC) 的作用,用于生物标志物识别.
研究的目的:
- 为了研究喘息患者在吸入曼尼托尔挑战后呼出的VOCs的变化.
- 为了确定与呼吸道炎症和支气管收缩相关的潜在的VOC生物标志物.
- 在有支气管过敏反应的个体中,区分曼尼托和假冒挑战之间的VOC概况.
主要方法:
- 招募患有喘或疑似喘的参与者.
- 吸入曼尼托尔挑战和假冒挑战的管理.
- 使用气体染色学-质谱仪在挑战前后对呼出的VOC进行分析.
主要成果:
- 曼尼托尔挑战改变了51种已识别的VOC中16种VOC的数量.
- 使用11种挥发性有机化合物的预测模型实现了13.8%的分类错误率.
- 与假冒挑战相比,在患有支气管对曼尼托尔过度反应的患者中观察到明显的挑战后的VOC标志.
结论:
- 吸入曼尼托尔与呼吸中的VOCs可测量的变化有关.
- 曼尼托尔挑战后的不同VOC表达可能表明急性气道炎症或支气管收缩.
- 这些VOC需要进一步研究,作为喘潜在的诊断生物标志物.
关键词:
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