针对阿尔茨海默病的抗胺单克隆抗体疗法:神经病学的新兴问题
Vijay K Ramanan1, Melissa J Armstrong1, Parichita Choudhury1
1From the Department of Neurology (V.K.R., L.K.J.), Mayo Clinic, Rochester, MN; Department of Neurology (M.J.A.), University of Florida College of Medicine; Norman Fixel Institute for Neurologic Diseases (M.J.A.), University of Florida, Gainesville; Cleo Roberts Center (P.C.), Banner Sun Health Research Institute, Sun City, AZ; Rocky Mountain Neurology (K.C.), Lone Tree, CO; Department of Neurology (R.H.H., D.A.W.), Department of Physical Medicine and Rehabilitation (R.H.H.), and Department of Psychiatry (R.H.H.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Abington Neurological Associates (B.C.K.), Ltd., Abington, PA; and American Academy of Neurology (S.R.W.), Minneapolis, MN.
针对粉样蛋白的新阿尔茨海默病 (AD) 治疗方法提供了希望,但需要大幅改变实践. 神经科医生需要调整工作流程,以便有效和公平地使用这些疾病修饰单克隆抗体 (mAbs).
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 新兴数据显示,lecanemab可以减缓早期症状性阿尔茨海默病 (AD) 的认知和功能衰退.
- 抗粉样类单克隆抗体 (mAbs) 代表了一类新的疾病修饰性治疗方法.
- 这些新的治疗方法带来了独特的风险和负担,与目前的AD管理策略不同.
结论:
- 疾病修饰治疗的出现标志着AD护理的新时代,需要神经病学实践的持续创新.
- 神经学实践必须做好准备和适应,以确保新出现的抗粉样蛋白 mAbs.的最佳患者结果.
- 解决当前知识的局限性和培养治疗和后续的灵活模式对于可持续的护理至关重要.
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