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大白发症和白风和甲状腺功能低下的发生在自身免疫多发性肌病-候选症-外皮缩症患者中
Hanna Englander1, Elise M N Ferré2, Monica M Schmitt2
1Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
自体免疫多发性肌病 - 候选症 - 皮肤外皮变 (APECED) 患者比一般人群更早地出现脱发性白发症 (AA). 在APECED中AA发作与白风和甲状腺功能低下相关,突出显示早期自身免疫性疾病的进展.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 皮肤病学 皮肤病学
背景情况:
- 自体免疫多发性肌病 - 候选症 - 外皮缩 (APECED) 是一种与粘膜皮肤候选症和自身免疫性疾病相关的遗传性免疫性疾病.
- 在一些APECED患者中观察到空白性脱发症 (AA),但其流行率,时间和与其他自身免疫性疾病 (如白风和甲状腺功能低下症) 的相关性尚未明确.
研究的目的:
- 在患有自身免疫多发性肌病 - 候群病 - 皮肤外 (APECED) 的患者中调查脱发区 (AA) 发病的时间.
- 在APECED队列中确定AA,白风和甲状腺功能低下症发病之间的相关性.
主要方法:
- 美国国家卫生研究院的一组自身免疫多发性肌病 - - 候选症 - - 皮肤外 (APECED) 队列的回顾性分析.
- 评估与APECED诊断相关的白 (AA),白风和甲状腺功能低下的发病时间.
主要成果:
- 与一般人群相比,白发症 (AA) 在自身免疫多发性肌病 - 候选症 - 皮肤外 (APECED) 队列中发生得更早.
- 亚亚很少是自身免疫性多发性肌内病症 - 候选症 - 皮肤外 (APECED) 的初始表现.
- 大发性脱毛症 (AA) 的发病与白风和甲状腺功能低下症的发病存在相关性,这两种疾病在这个队列中都很普遍,并且在很小的时候发生.
结论:
- 脱发性白发症 (AA) 是一种显著的皮肤表现在自身免疫多发性肌病 - 候选症 - 外皮缩症 (APECED) 患者,通常出现在早期的疾病过程中.
- 在APECED中,AA,白风和甲状腺功能低下的同时发病表明共享的自身免疫路径或加速的自身免疫进展.
- 对这些相关疾病的早期监测对于全面管理自身免疫多发性肌病 - 淋巴结核病 - 皮肤外 (APECED) 是至关重要的.
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