在荷尔斯泰因转向动物中注射鼻内催产素后,行为和心率的变化
Masumi Yoshida1,2, Kosuke Momita3,4, Masayoshi Kuwahara1
1Department of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
The Journal of veterinary medical science
|July 26, 2023
概括
鼻内催产素 (OXT) 并没有显著改变霍尔斯坦的行为或自主功能. 一个趋势表明,OXT可能会增加反时间,这表明潜在的中枢神经系统影响.
科学领域:
- 神经内分泌学神经内分泌学
- 动物行为 动物行为
背景情况:
- 催产素 (OXT) 是一种神经,影响大脑功能,如记忆力和应激反应.
- 之前的研究表明,OXT通过牛的脑内管内给药来表现出抗压力作用.
- 鼻腔内施用OXT为研究OXT的影响提供了一种非侵入性和实用的输送方法.
研究的目的:
- 为了研究鼻内催产素 (OXT) 给药对霍尔斯坦方向的行为和自主神经系统的影响.
- 为了评估不同OXT剂量 (100微克和200微克) 与盐水对照相比的影响.
- 评估注射鼻内OXT对中枢神经系统的潜在影响.
主要方法:
- 在主题内设计涉及六个霍尔斯坦牛.
- 内注射盐水 (SAL),100微克的OXT (OXT100) 或200微克的OXT (OXT200).
- 电心电图用于心率变化 (HRV) 分析和90分钟的行为观察.
主要成果:
- 在OXT200组中,躺着反时间的增加趋势显现 (P=0.053).
- 没有观察到OXT治疗对心率变化指数 (HRV) 的显著影响.
- 当前注射鼻内OXT的剂量并没有对整体行为或自主神经系统活动产生显著的变化.
结论:
- 在测试剂量的鼻内催产素给药并没有显著影响霍尔斯坦牛的行为或自主神经系统.
- 观察到的反活动增加的趋势表明OXT的潜在中心效应,需要进一步调查.
- 可能需要进一步研究调整剂量或不同的施用途径,以阐明牛群中OXT的全部作用.
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