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抗氧化剂对男性精液参数的作用:一个网络元分析

Arcangelo Barbonetti¹, Daniele Tienforti¹, Chiara Castellini¹

¹Andrology Unit, Department of Clinical Medicine, Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

|July 26, 2023

概括

含有或不含l-乙-卡尼丁的L-卡尼丁是最有效的抗氧化剂,可以改善异常性基-基-基精子 (OAT) 的男性的精子度,运动性和形态学. 其他抗氧化剂对特定参数显示有好处.

科学领域:

生殖医学生殖医学
药理学药理学是指药理学的学科.
基于证据的医学基于证据的医学.

背景情况:

抗氧化剂被广泛用于男性的不孕能力 (oligo-astheno-teratozoospermia,OAT).
有限的对比研究阻碍了最佳的抗氧化剂选择.
网络元分析 (NMA) 为比较多种治疗方法提供了一个强大的方法.

研究的目的:

评估各种抗氧化剂在使用NMA的异常性OAT中改善精液参数的疗效.
建立不同抗氧化剂制剂的有效性等级.

主要方法:

对主要数据库 (PubMed,Scopus,Cinahl,Cochrane) 的系统搜索确定了相关的随机对照试验 (RCT).
来自29个RCT的数据涉及2045名患有异常性OAT的男性,并使用随机效应的NMA进行了分析.
使用积累性排名曲线下的表面 (SUCRA) 排名治疗疗效.

主要成果:

与安慰剂相比,L-卡尼丁,特别是与l-乙-卡尼丁 (LAC) 结合,在精子度,渐进性运动性和形态学方面表现出最高的SUCRA.
叶酸还在改善精子度方面表现出有效性.
与或相结合的维生素E对总运动性最有效,而氧菲林和维生素E+CoQ10对渐进性运动性有好处.

结论:

L-卡尼丁和l-乙-卡尼丁代表了一种高度有效的抗氧化剂策略,用于改善异常性OAT中的关键精子参数.
特定的抗氧化剂组合为不同的精液质量方面提供了有针对性的好处.
NMA为指导男性不孕症抗氧化剂治疗的临床选择提供了有价值的证据.

关键词:

麦麦麦在线这就是ROSOS ROS.氧化应激是一种氧化应激.精子形态和体质精子形态和体质精子运动性精子运动性

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