作为CRSwNP严重程度的标志物,表皮内透的埃索诺菲尔杆细胞模式是CRSwNP严重性的标志
Matteo Gelardi1, Rossana Giancaspro2, Loren Duda3
1Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Via Luigi Pinto 1, 71122, Foggia, Italy.
Scientific reports
|July 26, 2023
概括
鼻息肉中的母细胞 (MCs) 与严重性鼻息肉 (CRSwNP) 的慢性鼻炎相关. 内皮质MCs表明更严重的疾病,建议为量身定制的治疗提供新的诊断标准.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 带有鼻息肉的慢性鼻炎 (CRSwNP) 是一种2型异性疾病.
- 乳腺细胞 (MCs) 在CRSwNP病原发生中的作用未被充分认识到.
- CRSwNP的混合埃索诺菲尔-MC形式显示出更高的复发风险.
研究的目的:
- 为了研究鼻聚体中巨细胞 (MCs) 的存在和局部.
- 为了将MCs与CRSwNP严重程度和埃索诺菲尔细胞计数相关联.
- 为了比较细胞学和组织病理学方法用于MC检测.
主要方法:
- 对39个鼻息肉样本进行了组织病理学和细胞学检查.
- 在上皮层和膜自身层中,酸酶+CD117+MCs的免疫组织化学.
- 统计分析以确定相关性和切线值.
主要成果:
- 皮质内MC和CRSwNP严重程度 (p<0.001) 之间存在显著的相关性.
- 总胆固醇和总MC计数有显著的相关性 (p<0.001).
- 细胞学和免疫组织化学显示出可比的内皮细胞MC检测 (p=0.002).
- 6个内皮质MC的切断线确定了严重的CRSwNP (p<0.001).
- 拉米纳自身MCs在乙性CRSwNP中很常见,但与严重程度无关.
结论:
- 内皮质巨细胞与CRSwNP严重程度的增加显著相关.
- 应确定对CRSwNP的异osinophil-MC形式的组织病理学标准.
- 定义这些标准可以导致更有效,个性化的患者治疗.
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