乳腺癌诊断和手术之间的时间间隔与疾病结果有关
Siji Zhu1, Shuai Li1, Jiahui Huang1
1Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Scientific reports
|July 26, 2023
概括
在诊断后将乳腺癌手术推迟超过两周,与较差的生存结果有关. 建议进行早期手术干预,以改善乳腺癌患者的预后.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 流行病学 流行病学
背景情况:
- 乳腺癌诊断和手术之间的时间间隔对患者和临床医生来说是一个重要的关注点.
- 这段时间间隔对患者生存结果的影响仍然不完全理解.
研究的目的:
- 研究从乳腺癌诊断到手术的时间间隔与患者生存结果之间的关联.
- 确定手术延长时间 (TTS) 是否影响乳腺癌无间隔 (BCFI) 和整体存活率 (OS).
主要方法:
- 在2009年至2017年期间诊断和治疗的5130名乳腺癌患者的回顾性分析.
- 根据手术的时间,患者被分为三组:≤1周,1-2周和>2周.
- 使用卡普兰-梅尔曲线和多变量分析分析了生存结果 (BCFI和OS).
主要成果:
- 在Ruijin队列 (3144名患者) 中,TTS>2周与5年BCFI (HR=1.80) 和OS (HR=2.07) 与TTS ≤1周相比显著较低.
- 在综合队列 (5130名患者) 中,5年BCFI和OS率在>2周TTS组 (BCFI: 78.9%,OS: 91.5%) 与≤1周组 (BCFI: 91.0%,OS: 95.8%) 相比显著较低.
- 统计学意义 (p < 0.001) 观察到联合队列的生存差异.
结论:
- 乳腺癌诊断后的手术延长时间 (>2周) 与不良疾病结果有关.
- 诊断后早期启动手术治疗至关重要,应继续进行,以提高患者的生存率.
- 这些发现强调了及时手术干预对优化乳腺癌管理的重要性.
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