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5-HT2AR和NMDAR迷幻药在老鼠的认知 - 边缘皮层 - 基底腺系统中诱导类似的超同步状态

Ivani Brys1,2,3, Sebastian A Barrientos1,3, Jon Ezra Ward1

  • 1The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden.

Communications biology
|July 26, 2023
PubMed
概括

像LSD和胺这样的迷幻药物诱导大脑振荡的超同步,影响知觉和认知. 这种广泛的脑信号同步可能解释了改变的状态,并为新的抗精神病治疗提供了目标.

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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