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[18F]flubrobenguane在临床成像群体中的药理和代谢参数
Braeden A Mair1,2, Jason G E Zelt2,3, Kirabo Nekesa1,2
1Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.
概括
[18F]flubrobenguane (FBBG) 显示了可靠的心交感神经系统 (SNS) 成像,具有方便的半衰期. 它的快速清除意味着疾病特异性校正对于各种患者群体的标记物动力学建模不那么重要.
科学领域:
- 核医学就是核医学.
- 分子成像学分子成像学
- 心脏病学 心脏病学
背景情况:
- 心脏交感神经系统 (SNS) 图像提供预后见解.
- [18F]flubrobendane (FBBG) 为SNS内化评估提供了对meta-[11C]hydroxyephedrine的一个方便的替代品.
- FBBG提供了更实用的物理半衰期和类似的分析方法.
研究的目的:
- 评估FBBG的药理动力学和代谢特性.
- 在不同的临床群体中评估FBBG特性,包括健康个体,非缺血性心肌病,缺血性心肌病和创伤后应激障碍.
- 为了确定这些特性对标记器动力学建模的影响.
主要方法:
- 在20名参与者身上进行了FBBG PET成像和血液采样,分为四个队列.
- 来自图像的时间活动曲线被转换为等离子体输入函数.
- 针对血蛋白结合,血至全血分布和新陈代谢的队列特异性校正被应用.
主要成果:
- 血与全血的比率因队列而异, (N) ICM在20分钟时显示了最低的比率 (0.60±0.14).
- 大约22%的FBBG与血蛋白结合.
- 与PTSD/NORM相比,在 (N) ICM (10分钟) 中观察到延迟的FBBG代谢 (0.71个父分数),而在PTSD/NORM (10分钟) 中观察到0.53个父分数).
- 尽管有代谢变化,但代谢物校正的血输入功能在所有队列中保持一致.
结论:
- 快速的FBBG血清除简化了标记物动力学建模.
- 由于FBBG的快速清除,对输入血液功能的疾病特异性纠正的影响有限.
- 在各种临床条件下,FBBG是用于心脏SNS成像的有前途的放射追踪器.
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