自闭症谱系障碍 (ASD) 与视力问题之间的关联. 一个系统的审查和元分析
John Perna1,2, Alessio Bellato3, Preethi S Ganapathy4
1Department of Psychiatry and Behavioral Sciences, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA.
Molecular psychiatry
|July 26, 2023
概括
自闭症谱系障碍 (ASD) 与各种视力和眼睛问题有关,包括视和对比度敏感性降低. 需要进一步的研究来了解ASD和生命早期视力障碍之间的因果关系.
科学领域:
- 眼科医生 眼科 眼科
- 神经发育障碍 神经发育障碍
- 公共卫生 公共卫生
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 眼睛和视觉系统异常经常在ASD患者中报告.
- 这些视觉关联的精确性质和程度需要进行系统的调查.
研究的目的:
- 系统地审查和对自闭症谱系障碍和视力/眼睛障碍之间的关联进行现有证据的元分析.
- 量化ASD患者特定视力障碍的患病率.
主要方法:
- 在多个电子数据库 (PubMed,知识/科学网络,Ovid Medline,Embase,APA PsycINFO) 进行了全面的搜索.
- 包括报告视力测量ASD或视力障碍患者ASD患病率的观察性研究.
- 进行了随机效应元分析,以综合来自46项涉及超过1500万个人的研究的数据.
主要成果:
- 发现自闭症症和的发病率增加之间存在显著的关联 (OR=4.72).
- 患有自闭症的个体表现出增加的适应缺陷,减少外围视力,减少立体急性,增加色彩歧视困难,减少对比度敏感性和增加视网膜厚度.
- 对于大多数结果,研究之间的异质性通常是无意义的.
结论:
- 自闭症谱系障碍与一系列功能视力问题和结构性眼睛改变有关.
- 包含的研究中的方法限制需要谨慎的解释.
- 未来的研究应该旨在阐明早期视力问题与ASD之间的因果关系.
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