周动脉脂肪放射学纹理特征与冠状动脉分数增加有关-光子计数-CT上的第一个结果
Peter Mundt1, Hishan Tharmaseelan1, Alexander Hertel1
1Department of Radiology and Nuclear Medicine, University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
对周心脏脂肪组织的放射学分析揭示了与冠状动脉化相关的纹理差异. 这些发现表明,放射性特征可能成为未来的心血管疾病风险评估的生物标志物.
科学领域:
- 心血管成像和辐射学
- 医学物理 医学物理
- 生物标志物发现发现
背景情况:
- 心血管疾病是全球死亡的主要原因之一.
- 脂肪组织与心血管疾病风险,全身炎症和血管化有关.
- 使用放射学分析脂肪组织的纹理分析为研究这些联系提供了一种新的方法.
研究的目的:
- 为了研究放射性特征的潜力从周心脏脂肪组织来区分患者基于冠状动脉化.
- 为了确定与心血管疾病风险标志物相关的特定放射性特征.
主要方法:
- 55名使用第一代光子计数CT的患者的回顾性分析.
- 手动细分周心脏脂肪组织,并使用pyradiomics提取106个放射性特征.
- 包括随机森林分类和物流回归在内的统计分析,以确定区分特征.
主要成果:
- 两个更高阶的放射性特征,glcm_ClusterProminence和glcm_ClusterTendency,在冠状动脉化和没有冠状动脉化的患者之间有显著差异 (阿加斯顿分数≥100).
- "glcm_ClusterProminence"被确定为主要的区分特征.
- 周心脏脂肪组织的纹理变化与冠状动脉分数相关.
结论:
- 经过放射学分析的周周血管脂肪组织质地显示与冠状动脉化存在相关性.
- 这些发现表明,周血管脂肪组织中炎症或纤维性活性可能起作用.
- 从脂肪组织中获得的放射性特征可能会成为心血管风险分层的有价值生物标志物.
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