人体免疫缺陷病毒阴性患者与抗干扰素-γ自身抗体的多重耐火细胞内病原体感染:一个病例报告
Hongxia Wang1,2, Rong Lei3, Yang Ji4
1Respiratory and Critical Care Medicine, The University of Hong Kong - Shenzhen Hospital, 1, Haiyuan 1St Road, Futian District, Shenzhen, Guangdong, China. wanghx5@hku-szh.org.
BMC infectious diseases
|July 26, 2023
概括
与抗干扰素- (IFN-γ) 自体抗体的成年期免疫缺陷呈现变化. 早期诊断和分子检测对于管理受影响个体的细胞内感染至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 与抗干扰素- (IFN-γ) 自体相关的成人发病免疫缺陷可以呈现出各种临床表现.
- 呈现的变化往往导致细胞内病原体感染的延迟诊断.
研究的目的:
- 报告一个患有抗IFN-γ自身抗体的成年期免疫缺陷患者的复杂病例.
- 突出这些患者的诊断挑战和机会性感染的管理.
主要方法:
- 一个54岁的人类免疫缺陷病毒阴性男性的病例研究,具有抗IFN-γ自身抗体.
- 详细的临床病史,包括复发性肺炎,扩散的Talaromyces marneffei,Mycobacterium kansasii和Listeria monocytogenes感染.
- 利用传统的微生物培养和下一代测序来识别病原体.
主要成果:
- 这位患者出现了复发性肺炎,传播了Talaromyces marneffei,Mycobacterium kansasii和Listeria monocytogenes的感染.
- 检测到高度的抗IFN-γ抗体.
- 结合抗NTM和抗菌疗法导致症状逐渐改善和骨破坏.
结论:
- 在患有不明原因的复发性细菌或机会性感染的患者中,应怀疑具有抗IFN-γ自身抗体的成年期免疫缺陷.
- 采用传统和先进的分子诊断技术对于准确的微生物鉴定在这个人群中至关重要.
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