牙周炎和COVID-19之间的潜在分子机制和生物标志物
Danlei Qin1,2, Feiyan Yu1, Dongchao Wu1
1Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, No 63, New South Road, Yingze District, Taiyuan, 030001, Shanxi, China.
BMC oral health
|July 26, 2023
概括
牙周炎和COVID-19具有共同的分子机制,涉及转录因子和淋巴细胞激活. 识别这些共同的途径为这两种疾病提供了潜在的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 新出现的证据表明牙周炎和严重的COVID-19结果之间存在联系.
- 牙周炎越来越被认为是COVID-19并发症的潜在风险因素.
研究的目的:
- 为了确定牙周炎和COVID-19背后的共同分子机制.
- 通过了解共享的病原性途径来探索潜在的治疗策略.
主要方法:
- 从牙周炎和COVID-19患者的RNA测序数据集的分析.
- 鉴定差异表达基因 (DEGs),生物过程和免疫细胞类型.
- 使用RT-PCR构建转录因子 (TF) -mRNA调节网络和验证.
主要成果:
- 在牙周炎中发现了1616个DEG,在COVID-19中发现了10201个DEG.
- 发现了9个共享的转录因子和与淋巴细胞激活相关的共同生物过程.
- 在这两种疾病中都观察到血细胞升高,RT-PCR证实了牙周炎中9个TF上调.
结论:
- 牙周炎和COVID-19的发病与转录因子表达和淋巴细胞激活有关.
- 这些共享的分子通路代表了管理牙周炎和COVID-19的潜在治疗点.
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