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早期70-180毫克/分升范围内的时间与急性胰腺炎患者的严重程度之间的关联
Chuchen Meng1, Jie Zhang1, Ying Wang1
1Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
在急性胰腺炎 (AP) 的早期阶段保持血糖时间范围 (TIR) 与更好的结果有关. 在AP患者中,早期血糖控制对于降低疾病严重程度至关重要,特别是在那些先前有良好的血糖管理的人群中.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
背景情况:
- 早期血糖控制和急性胰腺炎 (AP) 结果之间的关系尚不清楚.
- 这项研究调查了入院前72小时血糖时间范围 (TIR) 与AP进展之间的关联.
研究的目的:
- 为了确定早期血糖控制,特别是TIR (70-180毫克/分升),是否会影响急性胰腺炎的严重程度.
- 评估TIR对中度至重度AP的预测值,考虑到先前的血糖控制 (HbA1c水平).
主要方法:
- 在2017-2021年期间入院的298名AP患者的回顾性评估.
- 在前72小时内计算TIR百分比,并对AP严重程度进行分类 (MAP,MSAP,SAP).
- 使用后勤回归和ROC曲线分析,按HbA1c水平分层 (≤6.5%与<6.5%).
主要成果:
- TIR独立地与AP严重程度的降低有关 (OR=0.962,p=0.001),特别是在HbA1c ≤6.5% (OR=0.928,p=0.001) 的患者中.
- 一个TIR≥70%与降低的严重程度仅在患者与良好的前例血糖控制 (OR=0.238,p=0.020) 相关.
- 在前例控制较差或HbA1c<6.5%的患者中,TIR对AP严重性的预测能力有限.
结论:
- 早期血糖时间范围 (TIR) 与AP严重程度独立相关.
- 在AP的早期阶段有效的葡萄糖控制对具有良好的前代血糖控制的患者尤其有益.
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