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Updated: Jul 21, 2025

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

鱼阴性BCR::ABL1阳性e19a2慢性髓性白血病:插入中最神秘的插入

Philippa C May^1,2, Alistair G Reid³, Mark E Robinson⁴

¹Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK.

BMC medical genomics

|July 26, 2023

概括

这项研究呈现了一种罕见的慢性髓性白血病 (CML) 病例,最初在标准诊断测试中错过了. 全基因组测序发现了一个BCR::ABL1融合基因,突出显示了它在复杂的CML诊断中的实用性.

科学领域:

血液学血液学血液学
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

慢性髓性白血病 (CML) 的特征是BCR::ABL1融合基因,通常通过型定型或FISH检测.
一部分CML患者缺乏可见的转位,这给诊断带来了挑战.
亚微观插入可以创建BCR::ABL1融合基因无法通过标准细胞遗传方法检测到.

关键词:

BCR:ABL1 BCR:ABL1 BCR:ABL1 BCR:ABL1 BCR:ABL1 BCR:ABL1 BCR:ABL1 这是神秘的,神秘的.一个错误的负面.融合基因是一个融合基因.骨髓状细胞是什么? 骨髓状细胞是什么?

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