类风湿性关节炎的关节外表现仍然是一个重大挑战:来自大型多中心队列的数据
Karina Rossi Bonfiglioli1, Ana Cristina de Medeiros Ribeiro2, Ana Paula Carnieletto3
1Serviço de Reumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Av.Dr. Arnaldo, 455 - 3º andar - Reumatologia, São Paulo, SP, 01246-903, Brazil. karina.bonfiglioli@hc.fm.usp.br.
Advances in rheumatology (London, England)
|July 26, 2023
概括
类风湿性关节炎的关节外表现 (ExtRA) 影响23.4%的患者,通常与疾病持续时间延长和疾病活性增加有关. 这些发现突显了Extra在RA患者中持续存在的风险.
科学领域:
- 类风湿病学 类风湿病学
- 临床流行病学临床流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特征是关节炎症.
- 虽然RA的关节外表现 (ExtRA) 正在减少,但仍然是一个重要的死亡风险因素.
- 了解ExtRA的患病率和相关因素对于患者管理至关重要.
研究的目的:
- 为了确定在一大群RA患者中ExtRA的患病率.
- 调查ExtraRA与人口和临床变量之间的关联.
- 识别导致ExtRA.发展的关键因素.
主要方法:
- 一项采用多中心前性队列数据库的横截面观察性研究.
- 来自11个公共风湿病学中心的1115名RA患者被纳入.
- 统计分析包括曼·惠特尼U测试和费舍尔精确或奇方测试,显著性设置在p<0.05.
主要成果:
- ExtRA的总体患病率为23.4% (261/1115名患者).
- 接受ExtRA治疗的患者的年龄,疾病持续时间,类风湿因子 (RF) 标位,CDAI,DAS 28和HAQ分数显著增加.
- 在ExtRA组中观察到阿扎西奥普林,埃坦尼塞普特,葡萄糖皮质类药物 (GC) 和NSAIDs的使用增加.
结论:
- 在类风湿性关节炎 (RA) 中,关节外表现 (ExtRA) 仍然经常发生,不应被忽视.
- 长期的血清阳性疾病,严重的残疾和持续的炎症是ExtRA发展的关键因素.
- 这些发现强调了需要继续监测和管理风险为ExtRA的RA患者的需要.
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