新的诺克洛二二酸盐来自Dioscorea bulbifera的球茎
Apisara Somteds1, Somdej Kanokmedhakul1, Jantana Yahuafai2
1Natural Product Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
从 Dioscorea bulbifera bulbils.中分离出了两个新的诺克洛丹二类化合物. 一些化合物表现出细胞毒性,并抑制了巨细胞中氧化的产生.
科学领域:
- 自然产品 化学 化学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 气 (Dioscorea bulbifera L.) 是一种具有传统药用历史的植物.
- 植物化学研究对于识别药用植物中的生物活性化合物至关重要.
- 诺克莱罗丹二甲类代表了一类具有多样化生物活动的天然产品.
研究的目的:
- 从Dioscorea bulbifera L.的球泡中分离和描述新的和已知的化合物.
- 评估分离的化合物的细胞毒性和抗炎性潜力.
主要方法:
- 使用色谱技术提取和分离化合物.
- 使用光谱方法 (NMR,MS) 阐明结构.
- 通过X射线晶体学和电子循环二元化 (ECD) 谱学确定绝对配置.
- 对HelaS3细胞系进行细胞毒性测定.
- 氧化 (NO) 生产抑制测定在脂聚糖 (LPS) 诱导的RAW 264.7巨细胞中.
主要成果:
- 确定了两种新的诺克莱罗丹二甲,即迪奥斯布尔宾N乙酸 (1) 和-迪奥斯布尔宾B (3).
- 11个已知的化合物也被分离和描述.
- 7,9和10型中对HelaS3细胞具有中度的细胞毒性 (IC50值在9.03~27.13μM之间).
- 化合物7-9和11在LPS诱导的RAW 264.7巨细胞中显示出强大的NO生产抑制.
结论:
- 对 Dioscorea bulbifera bulbils 的植物化学研究导致发现了新型的二类植物.
- 一些孤立的化合物具有显著的细胞毒性和抗炎性质.
- 这些发现支持了Dioscorea bulbifera的民族植物学用途,并突出了其作为新治疗剂来源的潜力.
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