青少年脊椎关节炎疾病活动指数是有关炎关节炎的有用工具:现实生活数据
Merve Cansu Polat1, Zahide Ekici Tekin1, Elif Çelikel1
1From the Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara City Hospital.
概括
持续高的青少年脊椎关节炎疾病活动指数 (JSpADA) 在肠炎相关关节炎 (ERA) 患者的得分预测在六个月内持续活跃的疾病. 这一发现有助于早期识别和管理ERA. 关键词:ERA,JSpADA,活动性疾病,预测.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 肠炎相关关节炎 (ERA) 是青少年异常性关节炎的一个重要亚型.
- 了解疾病活动的预测因素对于有效管理至关重要.
- 青少年脊椎关节炎疾病活动指数 (JSpADA) 是评估疾病活动的工具.
研究的目的:
- 为了在六个月内比较具有活跃与非活跃疾病的ERA患者.
- 在ERA中确定疾病不活性的基线预测因子.
- 评估JSpADA对预测活跃ERA的实际影响.
主要方法:
- 在2009年6月至2022年6月期间诊断出56名ERA患者的回顾性医疗记录审查.
- 收集人口统计,临床和实验室数据以及JSpADA分数.
- 分析六个月的疾病活动和预测因素.
主要成果:
- 活跃和不活跃组之间在基线特征 (性别,年龄,关节参与,神经炎) 中没有显著差异.
- 在第3个月的红细胞沉率显著不同 (p=0.018).
- 第三个月的JSpADA中位数在活跃组 (1.5) 与不活跃组 (0.5) 中显著更高,p=0.037. 在第3个月的JSpADA截止值为1预测了在第6个月的持续活跃疾病 (AUC=0.662,p=0.042).
结论:
- 随访时持续升高的JSpADA分数是ERA患者在六个月后活跃疾病的预测因素.
- 该JSpADA在预测疾病持续性方面展示了现实世界的实用性.
- 通过JSpADA早期识别活跃疾病可以指导治疗调整.
相关概念视频
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
01:30Inflammatory Bowel Disease II: Crohn's Disease
296
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
296
01:19Pericarditis II: Clinical Features and Diagnostic Tests
9
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
9
01:20The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
01:26Nephrotic Syndrome II : Assessment and Medical Management
8
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
8
01:21Rheumatic Heart Disease III: Medical Management
20
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
20