一个框架,以了解偏见的来源在药物坚持研究研究的框架
Klarissa A Sinnappah1, Dyfrig A Hughes2, Sophie L Stocker3,4
1School of Pharmacy, University of Otago, Dunedin, New Zealand.
British journal of clinical pharmacology
|July 27, 2023
概括
这项研究在药物坚持性研究中发现了23个偏差,其中包括11个特定于坚持性措施的偏差. 一个新的框架将这些偏见映射到坚持阶段,以改善研究设计和风险评估.
科学领域:
- 药理学和制药学 药理学和制药学
- 临床研究方法论 临床研究方法论
背景情况:
- 药物坚持性研究对于有效的治疗结果至关重要.
- 坚持研究中偏见的来源需要全面的探索,以确保可靠的发现.
研究的目的:
- 为了确定药物坚持研究中的潜在偏见.
- 开发一个框架,将已识别的偏差映射到药物坚持的各个阶段 (启动,实施,停止).
主要方法:
- 进行了文献搜索并审查了关键论文.
- 查阅了偏见目录.
- 开发了一个表格矩阵,将偏差映射到坚持阶段.
主要成果:
- 确定了23个与坚持性研究相关的独特偏见.
- 发现有11个偏见与坚持措施和指标有具体关系.
- 绘制框架揭示了不同坚持措施和指标的偏见类型和数字的变化,突出了诸如不可接受性和恐惧偏见等常见偏见.
结论:
- 开发的框架提供了一种结构化的方法,以了解依从性研究中的偏见.
- 这个框架可以指导设计更强大的遵守研究.
- 它将为药物坚持性研究提供专门的偏差风险工具的开发提供信息.
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