[一种乳腺癌的病例,在化疗后转变为状细胞癌的亚型]
Kazuya Konishi1, Jun Araya, Makoto Nagabuchi
1Dept. of Surgery, Sapporo Century Hospital.
Gan to kagaku ryoho. Cancer & chemotherapy
|July 27, 2023
概括
超塑性癌瘤是一种罕见而具有攻击性的乳腺癌,在治疗后可以从侵入性导管癌转变为侵袭性导管癌. 这一案例凸显了管理这种侵略性亚型的挑战,强调了尽管进行了广泛的治疗,但预后不佳.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 医疗病例报告 病例报告
背景情况:
- 甲基塑性癌瘤是一种罕见的乳腺癌亚型,经常是三阴性,与预后不佳有关.
- 这个病例涉及一个最初被诊断为Luminal类型的侵入性导管癌的患者,后来发展为转移性/状细胞癌.
研究的目的:
- 报告一种罕见的乳腺癌从侵入性导管癌转变为转基因/状细胞癌的罕见病例.
- 为了说明管理晚期转移性癌症及其糟糕的结果所面临的挑战.
主要方法:
- 一名41岁的女性患者患有第四阶段左乳癌,接受了多种全身疗法的治疗.
- 在治疗期间对活检进行的组织病理学检查揭示了转移性/状细胞癌.
- 由于瘤的进展,患者接受了手术切除 (乳腺切除加上胸部主要肌肉切除).
主要成果:
- 原发性侵袭性导管癌转化为三重阴性转基因/状细胞癌,尽管各种治疗.
- 患者经历了显著的瘤进展,生活质量下降,最终在手术后一个月死亡.
- 包括BRCA,微卫星不稳定性和PDL1在内的诊断测试呈阴性.
结论:
- 代塑性癌症可以从其他乳腺癌亚型中产生,这对治疗提出了重大挑战.
- 侵袭性疾病进展和不良预后是这种罕见恶性瘤的特征.
- 需要进一步的研究来了解转变的机制,并开发有效的治疗方法.
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