目前关于关节骨关节炎中介细胞干细胞的证据:叙述性综述
Mina Entessari1, Leonardo P Oliveira2
1Florida International University, Herbert Wertheim College of Medicine, 11200 SW 8th Street, AHC2, Miami, FL 33199, USA.
Regenerative medicine
|July 27, 2023
概括
中介细胞干细胞注射对关节骨关节炎有希望,大多数研究报告患者报告的显著改善,没有重大并发症. 需要进一步的随机对照试验来确认疗效.
科学领域:
- 整形外科 整形外科 整形外科
- 再生医学是一种再生医学.
- 生物技术是生物技术.
背景情况:
- 关节骨关节炎是一种退行性关节疾病,治疗选择有限.
- 中介细胞干细胞 (MSCs) 正在探索它们在骨关节炎中的再生潜力.
- 目前关于用于关节骨关节炎的MSC注射的数据很少.
研究的目的:
- 系统地评估关于关节骨关节炎中介质干细胞注射的现有文献.
- 分析患者的结果,并比较包含的研究的方法.
- 评估MSCs在治疗关节骨关节炎中的安全性和临床有效性.
主要方法:
- 在PubMed,SportsDiscus和Case Reports上进行了全面的文献搜索.
- 使用的关键词包括"干细胞"",部"和"骨关节炎".
- 六项研究符合预定义的纳入和排除标准进行分析.
主要成果:
- 六项研究中的五项报告了MSC注射后患者报告结果的统计学上显著改善.
- 仅在两项研究中报告了放射性变化,结果是积极的.
- 在包括的研究中没有报告任何重大并发症,这表明了有利的安全性.
结论:
- 目前的证据表明,介质干细胞注射对于关节骨关节炎是安全和临床有效的.
- 小系列和非随机试验表明了积极的临床反应.
- 高质量的随机对照试验对于验证MSC作为关节骨关节炎的最终治疗方法至关重要.
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