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Updated: Jul 21, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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在多发性髓瘤中,PVT1与多镇压复合体2相互作用,以抑制具有亲亡和瘤抑制功能的基因组区域

Patrick Nylund1, Berta Garrido-Zabala2, Alba Atienza Párraga2

  • 1Science for Life Laboratory, Department of Immunology, Genetic and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala. patrick.nylund@igp.uu.se.

Haematologica
|July 27, 2023
PubMed
概括

长非编码RNA PVT1 与多发性骨髓瘤中EZH2相互作用,这是一个具有挑战性的血液癌症. 过度表达PVT1与预后不佳相关,这表明它是治疗这种疾病的潜在治疗标.

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