伤害 改善帕金森病通过调节肠道微生物结构和代谢障碍来改善帕金森病
1Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Heliyon
|July 27, 2023
概括
阿坎托帕纳克斯 (Acanthopanax senticosus,ASH) 提取物通过调节肠道微生物群和新陈代谢,可以改善帕金森病 (PD) 的小鼠的运动功能. 这项研究研究了ASH对PD模型中的肠道细菌和代谢物的影响.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 帕金森病 (PD) 是一种流行的神经退行性疾病,其发病因子不明.
- 人口老龄化正在经历PD发病率的增加,这对公众健康造成了重大关注.
- 一种传统的中国草药Acanthopanax senticosus (ASH) 显示出对PD的治疗潜力.
研究的目的:
- 研究ASH在治疗PD中的作用机制.
- 分析ASH对PD小鼠肠道微生物群结构和功能的影响.
- 在PD小鼠模型中检查ASH干预后便代谢物的变化.
主要方法:
- 使用了阿尔法-同核素转基因小鼠PD模型.
- 将ASH (水性乙醇提取物) 通过口腔给治疗组.
- 采用元基因组学和便代谢学 (UHPLC-MS/MS) 进行综合分析.
- 通过使用杆登时间和自主活动测试来评估运动功能.
主要成果:
- ASH干预改善了PD小鼠的运动功能,减少了爬时间并增加了自主运动.
- 甲基因组学揭示了ASH调节的肠道微生物群,在系级上对Firmicutes进行上调和对Actinobacteria进行下调.
- 代谢学发现阿尔法-烯酸代谢是受到ASH影响的关键途径,与不和脂肪酸合成和精氨酸代谢一起.
结论:
- 在PD模型中,ASH可以通过调节肠道微生物群的组成和功能来缓解运动障碍.
- ASH的治疗作用可能与特定代谢途径的调节有关,包括涉及不和脂肪酸和 purin代谢的代谢途径.
- 这项研究强调了肠道微生物群,宿主新陈代谢和PD之间的复杂联系,ASH作为治疗剂显示出希望.
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