癌症中的CXCL12-CXCR4/CXCR7轴:从机制到临床应用
Yaru Yang1,2, Jiayan Li1,2, Wangrui Lei1,2
1Department of Orthopedics, Shenmu Hospital, Faculty of Life Sciences and Medicine, Northwest University, Shenmu, China.
International journal of biological sciences
|July 27, 2023
概括
信号轴CXCL12-CXCR4/CXCR7在癌症发育中至关重要,影响癌症的增殖,转移和瘤微环境. 针对这一轴为新型癌症疗法和生物标志物提供了潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 癌症是由遗传/表观遗传变化引起的,这对全球健康构成了挑战.
- 细胞因子和化学因子失调在人类癌症中很常见,影响免疫功能和癌症进展.
- 化学因子,如CXCL12及其受体 (CXCR4,CXCR7) 在癌细胞行为中起着重要的作用.
研究的目的:
- 对癌症中CXCL12-CXCR4/CXCR7信号轴的最新研究进行审查.
- 要突出轴在癌症特征中的作用,如增殖,生存,血管新生和转移.
- 探索这个轴作为癌症生物标志物和治疗点的潜力.
主要方法:
- 关于CXCL12,CXCR4,CXCR7和癌症的科学出版物的文献综述.
- 分析CXCL12-CXCR4/CXCR7轴在各种癌症类型中的参与.
- 对轴对瘤微环境和癌症进展的贡献的当前理解的综合.
主要成果:
- 在CXCL12-CXCR4/CXCR7轴显著影响瘤细胞的增殖,生存,血管生成和转移.
- 这种信号通路与各种癌症的发展有关,包括白血病,乳腺癌,肺癌和前列腺癌.
- 这个轴上的异常会破坏平衡和免疫监测,导致癌症的发病和进展.
结论:
- CXCL12-CXCR4/CXCR7轴是癌症发展多个阶段的关键参与者.
- 向CXCL12-CXCR4/CXCR7通路为开发新型癌症疗法提供了一个有前途的战略.
- 这个轴有可能作为各种恶性瘤的诊断生物标志物.
关键词:
在CXCR4中,CXCR4是CXCR4.CXCR7CXCR7CXCR7CXCR7CXCR7CXCR7CXCR7CXCR7CXCR7癌症的进展情况.化学物质CXCL1212 化学物质CXCL12抑制剂 抑制剂 抑制剂更多相关视频
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