在工作场所心血管疾病预防计划中实施多基因风险评分的成本效益分析
Deo Mujwara1, Jen Kintzle1, Paolo Di Domenico1
1Allelica, Inc., New York, NY, United States.
Frontiers in public health
|July 27, 2023
概括
将冠状动脉疾病的多基因风险评分 (PRS) 纳入工作场所健康计划是具有成本效益的. 这种方法提高了员工的生活质量,降低了雇主成本,对预防心血管疾病有益.
科学领域:
- 预防心血管疾病预防心血管疾病
- 卫生经济学 卫生经济学
- 基因组学就是基因组学.
背景情况:
- 工作场所心血管预防计划是有效的,但结合冠状动脉疾病 (CAD-PRS) 多基因风险评分 (PRS) 的成本效益尚不清楚.
- CAD-PRS可以改善心血管疾病风险评估和预防.
- 工作场所为心血管健康干预提供了合适的环境.
研究的目的:
- 检查将CAD-PRS整合到工作场所心血管疾病预防计划中的成本效益.
- 将这个综合计划与标准的工作场所计划和没有工作场所计划进行比较.
主要方法:
- 开发了一个队列模拟模型来预测50岁以上的员工的健康益处 (质量调整的寿命年) 和5年内的成本.
- 该模型包括心血管疾病,中风和他类药物的副作用的健康状况,同时考虑医疗和生产力成本.
- 他们比较了三个场景:CAD-PRS集成程序 (CardioriskSCORE),标准工作场所程序 (标准WHP) 和没有程序 (没有WHP).
主要成果:
- 与标准WHP和无WHP相比,心脏风险SCORE计划将雇主成本降低了53-575美元,并将员工质量调整寿命年提高了0.001-0.005岁.
- 影响增量净货币收益的关键因素包括他类药物的有效性,基线心血管风险,计划入学和他类药物的坚持.
- 尽管参数输入的变化,基准案例结果仍然很强.
结论:
- 将多基因风险测试纳入职场心血管预防计划是具有成本效益的.
- 这种方法提高了员工的生活质量,同时降低了雇主的健康和生产力成本.
- 多基因风险评分为职业环境中精确心血管预防提供了有价值的工具.
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