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根据中国医院药监系统,对过敏反应进行积极监测和临床分析

Chengcheng Wang¹, Zejing Li², Yingying Yu¹

¹Department of Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.

Frontiers in pharmacology

|July 27, 2023

概括

使用中国医院药监系统 (CHPS) 的积极监测计划 (ASP) 与自发报告相比,显著改善了过敏反应的检测. 然而,过敏反应的管理,特别是上腺素的使用,需要紧急改进,以减少患者死亡风险.

科学领域:

药物监督药物监督药物监督
临床信息学临床信息学
过敏和免疫学过敏和免疫学

背景情况:

过敏反应报告不足是中国的一个重大挑战,阻碍了准确的发病率和管理评估.
中国医院药监系统 (CHPS) 提供了增强不良事件监测的潜力.
开发有效的积极监测计划 (ASP) 对于改善过敏反应检测和患者安全至关重要.

研究的目的:

开发和验证使用CHPS对过敏反应的积极监测计划 (ASP).
分析中国三级医院内过敏症病例的特征,常见的过敏原和管理策略.
将ASP的检测率与传统的自发报告系统进行比较.

主要方法:

向国家药物不良反应监测系统 (2014-2021) 报告的过敏反应病例的回顾性分析.
开发一个问卷和Delphi方法来识别过敏反应触发因素,并将其编程为ASP构建的CHPS.
对238,194名出院患者进行ASP测试,以评估绩效和分析临床数据.

主要成果:

三个ASP确定了76名患者经历了79次过敏反应事件,比自发报告增加了5.64倍.
抗菌药物,抗瘤药物和对比剂是最常见的过敏原;抗瘤药物发生率最高 (0.6%).
观察到显著的上腺素的使用不足和过度使用葡萄糖皮质类药物/抗组胺药物,与不适当的上腺素剂量和管理.

结论:

基于CHPS的ASP有效地利用结构化和非结构化数据来改善过敏反应的检测,解决报告不足的问题.
目前的过敏反应治疗和管理策略不足,需要改进以减轻死亡风险.
该研究强调了中国需要加强药物监测系统和标准化过敏反应管理协议的必要性.

关键词:

中国医院药监系统医院药监系统德尔菲的方法方法德尔菲方法.积极监督是指积极的监督.过敏反应是一种过敏反应.上腺素 (epinephrine) 是一种可以

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