影响糖尿病黄斑的强化治疗反应的因素:现实世界的研究
Ye Eun Han1,2, Jaehyuck Jo1,2, Yoon Jeon Kim1,2
1Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Republic of Korea.
Journal of diabetes research
|July 27, 2023
概括
密集的aflibercept注射改善了糖尿病黄斑胀 (DME) 的视力和视网膜厚度. 然而,较长的糖尿病持续时间,功能和膜存在预测对这种治疗的反应较差.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 正在探索强化治疗方案以改善DME的结果.
- 了解影响治疗反应的因素对于个性化医学至关重要.
研究的目的:
- 确定影响DME强化aflibercept治疗反应的全身和眼部因素.
- 评估在DME患者中强化aflibercept治疗方案的实际有效性.
主要方法:
- 从23名DME患者的30只眼睛进行了回顾性队列研究.
- 密集治疗:每月5次静脉注射aflibercept注射.
- 通过中枢视网膜厚度 (CRT) 和最佳校正视敏度 (BCVA) 评估的反应.
主要成果:
- 在加重剂量后 (p < 0.05) 观察到CRT和BCVA的显著改善.
- 53.33%的眼睛在12个月内没有进一步治疗,保持了CRT.
- 预测非最佳反应的因素包括:糖尿病持续时间较长 (≥15年),较低的EGFR (<80毫升/分钟/1.73米2),较高的血清肌素 (≥0.95毫克/分升),较高的 (≥4.7毫升/升) 和脑膜膜膜 (ERM).
结论:
- 强化aflibercept治疗在DME中产生了显著的解剖学和视觉效果.
- 低于最佳反应的预测因素包括特定的系统性 (糖尿病持续时间,功能标志物) 和眼部 (ERM) 因素.
- 这些因素有助于预测个体对DME强化治疗的反应.
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