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对免疫检查点抑制剂的皮肤免疫相关不良事件:从潜在的免疫机制到多omics预测预测
Ting Cao1, Xuyang Zhou1, Xingbiao Wu1
1Allergic Dermatoses Clinical Center, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Frontiers in immunology
|July 27, 2023
概括
免疫检查点抑制剂 (ICI) 可以引起皮肤副作用,称为皮肤免疫相关不良事件 (cirAEs). 多学科研究确定生物标志物来预测和理解这些毒性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经在各种恶性瘤中彻底改变了癌症治疗.
- 对ICI的一个重大挑战是与免疫相关的不良事件 (irAEs) 的发生,特别是皮肤上的irAEs (cirAEs).
研究的目的:
- 审查ICI诱导的皮肤病理IRE的频谱和发病因子.
- 为了总结预测cirAEs的多omics生物标志物.
- 在接受ICI治疗的患者中探索cirAEs的预后意义.
主要方法:
- 综合多omics数据 (基因组学,转录组学,蛋白质组学等) 的文献综述. 有临床信息.
- 对ICI诱导的皮肤毒性背后的免疫机制的分析.
- 对cirAEs的预测生物标志物进行当前研究的综合.
主要成果:
- 皮肤是ICI相关IRAE中经常受到影响的器官.
- 多omics方法正在揭示对免疫系统在cirAE发展中的作用的见解.
- 一些潜在的生物标志物正在从整合的奥米克和临床数据中出现,用于预测cirAEs.
结论:
- 了解cirAEs的致病性对于管理ICI治疗至关重要.
- 多主题研究为确定cirAEs的预测生物标志物提供了有希望的途径.
- CirAEs可能对免疫检查点阻塞治疗的疗效具有预后价值.
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