CD8+ T 细胞在子宫内膜异位症中的作用:系统性审查
Ana Kisovar1, Christian M Becker1, Ingrid Granne1
1Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom.
Frontiers in immunology
|July 27, 2023
概括
在子宫内膜异位症病变中,CD8 T细胞的数量较高,但它们在不孕症和疼痛中的作用尚不清楚. 需要进一步的研究来了解它们对潜在新疗法的功能.
科学领域:
- 免疫学 免疫学 免疫学
- 妇科 妇科医生 妇科
- 生殖医学 生殖医学
背景情况:
- 子宫内膜异位症影响6-10%的女性,导致不孕不育和疼痛.
- CD8 T 细胞在子宫内膜异位症中的作用尚不清楚.
- CD8 T 细胞与不孕症和其他疾病中的疼痛有关.
研究的目的:
- 系统地审查关于子宫内膜异位症中CD8T细胞的文献.
- 确定CD8T细胞在子宫内膜异位症和相关疾病 (如不孕症和盆腔疼痛) 中的病理生理学和临床相关性.
主要方法:
- 在四个数据库 (MEDLINE,EMBASE,Web of Science,CINAHL) 进行了搜索,直到2022年9月.
- 包括英语,对子宫内膜异位症患者和动物模型中CD8T细胞的同行评审论文.
- 不包括其他妇科病理,癌症,免疫疾病或激素治疗的研究.
主要成果:
- 包括28项研究,显示CD8 T细胞在子宫内膜病变中比eutopic子宫内膜丰富.
- 周围血液中CD8T细胞种群在患者和对照人群之间没有差异.
- 腹膜液和eutopic子宫内膜中的CD8 T细胞的证据是相互矛盾的;在月经排泄物中增加了细胞毒性.
结论:
- 关于子宫内膜异位症组织中CD8 T细胞的文献不一致.
- 在病变中增加CD8 T细胞水平,但激活潜力尚未研究.
- 未来的研究应该确定用于非侵入性诊断和治疗的临床相关的表型.
关键词:
CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD9 CD8 CD8 CD8 CD9 CD8 CD9 CD8 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 是一个字体的字体的字体是什么意思一个T细胞细胞.子宫内膜异位症是什么?子宫内膜异位症是什么这是子宫内膜的内分泌物.腹腔周围的液体更多相关视频
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