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奥米克朗阶段对日本一个高度先进的医疗设施的影响
Hirokazu Yamagishi1, Daisuke Tamura1, Jun Aoyagi1
1Department of Pediatrics, Jichi Medical University, Shimotsuke-shi, Japan.
Frontiers in pediatrics
|July 27, 2023
概括
儿童COVID-19患者,特别是在Omicron波之后,出现了和急性脑病变的增加. 虽然严重疾病的发病率保持稳定,但观察到过度细胞动力症和脑病综合征等关键并发症.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 疫情在日本已经发生了八次浪潮.
- 了解儿科COVID-19病例的临床特征至关重要.
研究的目的:
- 为了澄清日本儿科COVID-19患者的临床特征.
- 分析与COVID-19波浪有关的住院和严重疾病率.
主要方法:
- 在2020年4月至2023年3月期间入院的121名儿科患者的回顾性研究.
- 分析住院和重症病率使用县的发病率数据.
主要成果:
- 大多数住院 (91.7%) 发生在2022年1月 (第六波后) 之后,这与Omicron变种相吻合.
- 发作 (24.8%) 和急性脑病 (9.1%) 被发现,特别是在第六波之后以前健康的儿童中.
- 一名死因是脑病变综合征与高细胞因子症;两名患者有后续症状. 严重疾病的发病率在第六波之后没有显著变化.
结论:
- 尽管整体严重疾病的发病率稳定,但儿科COVID-19可能会导致严重的并发症,如严重脑病变.
- 系统性炎症反应与儿科COVID-19病例中严重脑病变的发展有关.
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