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欧洲叶提取物对大鼠模型中西斯普拉丁诱导的毒性的改善作用

Doa'a Ibrahim¹, Abdulsalam Halboup^1,2, Mohammed Al Ashwal³

¹Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Science and Technology, Sana'a, Yemen.

International journal of nephrology

|July 27, 2023

概括

欧洲叶提取物 (OELE) 显示出有前途的保护对青造成的脏损伤. 研究表明,OELE可以显著降低剂量取决于大鼠中西斯胺诱导的毒性.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
自然产品自然产品

背景情况:

欧洲叶提取物 (OELE) 具有已知的健康益处和对细胞损伤的保护作用.
西斯普拉丁是一种广泛使用的化疗剂,具有显著的毒副作用.

研究的目的:

为了研究Olea europaea叶提取物 (OELE) 在大鼠模型中对西斯普拉丁诱导的损伤的潜在保护作用.
评估OELE在减轻西斯甲毒性方面的剂量依赖性疗效.

主要方法:

鼠被分为六组,包括对照组,仅服用西斯,仅服用OELE,以及服用不同剂量的OELE的西斯.
西斯普拉丁是作为单次腹膜内注射剂,而OELE是口服10天.
通过测量血清肌素,血液尿素 (BUN),肌素清除率和水平,以及对组织的病学检查来评估功能.

主要成果:

西斯普拉丁的使用导致了显著的毒性指标,包括血清肌素和BUN的升高,以及肌素清除和水平的降低.
组织病理学分析证实了西斯丁治疗大鼠的脏组织损伤.
经过OELE的使用,西斯普拉丁诱导的毒性有显著的,剂量依赖的改善,改善了生化标志物和组织学.

结论:

橄叶 (Olea europaea) 叶片提取物在老鼠中表现出显著的保护作用,防止西斯胺诱导的毒性.
OELE代表了减轻化疗相关损伤的潜在治疗策略.

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