节奏变化的预后价值,一个新的6MWT衍生的特征,在患有慢性阻塞性肺病的患者中
Chun-Ta Huang1, Sheng-Yuan Ruan1, Feipei Lai2,3,4
1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
概括
在慢性阻塞性肺病 (COPD) 患者的6分钟步行测试 (6MWT) 中,速度变化更大表明死亡和住院的风险更高,预示着预后更差.
科学领域:
- 肺部医学 肺部医学
- 临床运动生理学 临床运动生理学
背景情况:
- 6分钟步行测试 (6MWT) 评估慢性阻塞性肺病 (COPD) 患者的功能能力.
- 6分钟步行距离 (6MWD) 和相关指标与COPD的死亡率和住院病例有关.
- 节奏变化,体育医学的一个措施,在6MWT期间在COPD患者中没有得到广泛的研究.
研究的目的:
- 调查COPD患者在6MWT期间节奏变化的预后价值.
- 为了确定步伐变化是否可以预测COPD患者的不良结果.
主要方法:
- 对163名参加绩效支付计划的COPD患者的回顾性分析 (2019年1月 - 2020年5月).
- 6MWT数据分为三个2分钟的时代,以计算每个时代的平均步行速度.
- 节奏变化定义为 (最大速度-最小速度) /整体平均速度.
- 主要结局:1年内因恶化而导致的死亡率或住院的综合结局.
主要成果:
- 在163名患者中,有19名患者 (12%) 经历了复合不良结果.
- 负面结果的独立预测因素包括%预测的6MWD<72 (aOR 7.080) 和步伐变化率≥0.39 (aOR 9.444).
- 患有任何一种不良特征的患者的无不良事件生存率明显降低 (日志数等级P < 0.005).
结论:
- 在6MWT期间速度变化的增加是COPD患者不良结果的重要独立预测因素.
- 慢性肺炎患者的节奏变化更高,死亡和住院的风险更高.
- 节奏变化提供了宝贵的预后信息,超出了COPD中传统的6MWD措施.
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