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细胞质链在早期人类胚胎发育过程中的重要性
Kata Joo1, Annamaria Nemes1, Beata Dudas1
1Division of Assisted Reproduction, Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary.
Frontiers in cell and developmental biology
|July 27, 2023
概括
人类胚胎中的细胞质链 (CS) 与更高质量的胚芽细胞和改进的发育指标有关. 它们的存在在81.2%的胚胎中被观察到,这表明它们的生存能力和植入潜力更高,而不管受精方法如何.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 在体外受精 (IVF) 中胚胎选择传统上依赖于形态评估.
- 目前的试管婴儿实践利用时间间隔成像进行形态动力学分析.
- 囊胞阶段的细胞质链 (CS) 是一种新可观测的特征.
研究的目的:
- 调查细胞质链 (CS) 的存在与人类IVF中的胚胎生存能力之间的关系.
- 为了比较具有和没有CS的胚胎的形态动力学参数和发育动态.
主要方法:
- 从78名试管婴儿患者中对208个人类胚胎的形态动力学数据进行评估.
- 在CS+和CS-组之间比较胚胎发育,形态和时间间隔得分 (KIDScore,iDAScore).
- 分析胚芽细胞的发育速度和达到胚芽细胞阶段的时间.
主要成果:
- 81.2%的囊胞表现出细胞质链 (CS+).
- 在CS+胚胎中,成长为高质量的胚芽细胞的比率显著更高 (52.1%对20.5%,p=0.02).
- CS+胚胎获得了更好的形态动力学分数 (KIDScore,iDAScore) 并更早地达到胚芽细胞阶段 (103.9h与107.6h,p=0.001).
结论:
- 细胞质链 (CS) 的存在在人体胚胎囊中很常见,与受精方法 (IVF与ICSI) 无关.
- CS+胚胎表现出增强的发育潜力,由优越的形态动力学参数和更早的胚胎细胞形成表明.
- 细胞质链是在试管婴儿治疗中增加胚胎活力和植入潜力的有希望的指标.
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