使用光学连贯性断层扫描仪对中耳进行几何精确的实时体积可视化
Joshua D Farrell1, Junzhe Wang1, Dan MacDougall2
1School of Biomedical Engineering, Dalhousie University, NS B3H 4R2, Canada.
Biomedical optics express
|July 27, 2023
概括
本研究介绍了一种新的手持系统,用于中耳的实时3D光学连贯性断层扫描 (OCT) 成像. 它实现了高的几何精度,使微妙的耳朵结构的详细可视化.
科学领域:
- 生物医学光学 生物医学光学
- 医学成像医学成像
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 准确的中耳可视化对于诊断和治疗各种疾病至关重要.
- 现有的成像模式在实时,高分辨率和中耳的几何精度方面存在局限性.
研究的目的:
- 开发和验证一种新的手持式光学连贯性断层扫描 (OCT) 系统,用于对中耳进行几何精确,连续,实时,体积成像.
- 评估系统捕获动态中耳过程的能力.
主要方法:
- 为了快速获取体积数据,采用了一种新的离散螺旋扫描 (DC-SC) 模式.
- 实时扫描转换和侧向角扭曲校正被应用,以尽量减少几何不准确性.
- 图像的几何精度与微型计算机断层扫描 (微型CT) 使用幻影和尸体样本进行了验证.
- 该系统的实时成像在健康受试者的Valsalva机动中进行了评估.
主要成果:
- 该系统实现了几何精确的,连续的,实时的,体积的中耳OCT成像.
- 几何不准确性被降低到低于系统的侧向分辨率超过92%的视野 (FOV).
- 对微型CT的验证证实了系统的几何精度.
- 在瓦萨尔瓦演习期间,动态中耳成像展示了系统的实时能力.
结论:
- 开发的手持OCT系统提供了中耳的几何精确,实时,体积成像.
- 这项技术有可能显著改善中耳病理的诊断和理解.
- 该系统对动态过程的成像能力为耳鼻喉科的研究和临床应用开辟了新的途径.
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