结肠附着的输送系统具有炎症反应能力,用于实验性结肠炎局部治疗
Ajay Kumar1, Kanika1, Vibhu Kumar2
1Chemical Biology Unit, Institute of Nano Science and Technology, Sector-81, Knowledge City, Sahibzada Ajit Singh Nagar, Mohali, Punjab 140306, India.
ACS biomaterials science & engineering
|July 27, 2023
概括
这项研究引入了一种酶响应的水凝,用于性结肠炎 (UC) 治疗,改善药物输送和减少炎症. 这种新型的水凝增强了布索尼德的保留和释放,为治疗大肠炎提供了对传统阴囊的有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 药物输送系统 药物输送系统
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,影响结肠和直肠.
- 目前用于UC的治疗阴道水患有药物保留不良和低生物可用性.
- 传统阴囊疗法的局限性需要创新的药物输送方法,以改善治疗结果.
研究的目的:
- 开发一种酶响应的可注射水凝 (ER-水凝),用于增强性结肠炎治疗药物输送.
- 克服传统阴囊的局限性,特别是保持不良和药物的可用性.
- 在硫酸 (DSS) 诱导的UC模型中,评估布松胺载荷ER-水凝的物理化学和治疗疗效.
主要方法:
- 使用热冷方法配制ER-水凝,用封装的布德化物 (Bud) 制成.
- 在体外和体外粘膜粘附研究以评估水凝保留.
- 使用酶来确认按需释放的酶响应性药物释放研究.
- 在DSS诱导的UC小鼠中评估治疗疗效,包括疾病活性,结肠长度,组织组织学和炎症标志物 (IL-1β,TNF-α,MPO,酸盐).
主要成果:
- 埃尔-凝显示出显著的粘粘度,确保长时间保留在结肠.
- 雌激酶触发了水凝中大量释放的布德索尼德,证实了酶介导的药物递送.
- 用芽装载的ER-水凝有效地减轻了UC疾病的活动,恢复了结肠的长度,改善了结肠组织组织学.
- 在血清和结肠组织中观察到关键炎症标志物 (IL-1β,TNF-α,MPO,酸盐) 的显著减少.
结论:
- 开发的充满布索尼德的ER-水凝为性结肠炎治疗提供了一个有前途的策略,可以增强药物保留和控制释放.
- 这种创新的水凝配方显著改善了实验性结肠炎的炎症变化,优于传统的阴囊疗法.
- 该ER-水凝表现出相当大的翻译潜力,以提高治疗疗效在炎症性肠病管理.
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