访问到访问的葡萄糖变化,认知和全球认知衰退:动脉样硬化多民族研究
Christopher L Schaich1, Michael P Bancks2, Kathleen M Hayden3
1Department of Surgery, Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
The Journal of clinical endocrinology and metabolism
|July 27, 2023
概括
较高的葡萄糖变性 (GV) 与老年人的认知功能较差有关. 这种效应在2型糖尿病 (T2D) 患者中更为明显,表现出认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 访问到访问的葡萄糖变化 (GV) 与失糖症和2型糖尿病 (T2D) 有关.
- 二型糖尿病和糖尿病是认知能力下降的危险因素.
- 了解GV对认知的影响对于老龄化人口至关重要.
研究的目的:
- 评估GV和认知表现之间的关联.
- 评估GV与各种老年人的认知衰退的联系.
- 在患有和没有T2D的个体中检查这些关联.
主要方法:
- 从4367名参与者的6次临床检查中计算出葡萄糖变化指标 (SDG,ARV,VIM).
- 使用CASI和数字符号编码测试评估认知表现.
- 使用多变量回归,调整心血管风险因素和平均葡萄糖.
主要成果:
- 增加的VIM和SDG与较差的CASI表现有关.
- 增加的VIM和ARV与较差的数字符号编码得分有关.
- 在发生T2D的参与者中,SDG和VIM预测了CASI下降,与单一时间点葡萄糖或HbA1c不同.
结论:
- 16-18岁以上的高访客GV与一般人群的认知表现较差相关.
- 在T2D患者中,GV与适度的全球认知衰退有关.
- 葡萄糖含量,而不仅仅是平均葡萄糖,是老年人认知健康的重要因素,特别是T2D患者.
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