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Cilta-cel是一种针对BCMA的CAR-T疗法,用于重度预治疗的复发/耐药多发性髓瘤患者

Thomas G Martin¹, Deepu Madduri², Lida Pacaud³

¹Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA.

Future oncology (London, England)

|July 27, 2023

概括

Cilta-cel是一种仿真抗原受体T细胞疗法,在多发性骨髓瘤患者中显示出高响应率. 这种针对BCMA的疗法提供了一个有前途的治疗选择,具有可控的副作用.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
细胞疗法细胞疗法

背景情况:

多发性骨髓瘤是一种血液性恶性瘤,对复发性或耐药性疾病的治疗选择有限.
化学抗原受体 (CAR) T细胞疗法已成为一种新的治疗策略.

研究的目的:

评估ciltacabtagene autoleucel (cilta-cel) 的疗效和安全性,这是一种向B细胞成熟抗原 (BCMA) 的CAR T细胞疗法.
在复发性或耐火性多发性髓瘤患者中评估cilta-cel.

主要方法:

关键的CARTITUDE-1试验评估了在复发性或耐火性多发性髓瘤患者中使用西尔塔细胞.
患者之前至少接受过3或4种疗法,包括标准治疗.

主要成果:

Cilta-cel的整体响应率高达98%,其中83%的患者在28个月的中位数随访后获得了严格的完整响应.
没有达到无进展生存的中位数,这表明持续的反应.
副作用可以通过支持性治疗来控制.

结论:

Cilta-cel是复发性或耐火性多发性髓瘤的有效和安全治疗方法.
对早期治疗方法和最佳序列的进一步研究是有必要的.

关键词:

在B细胞成熟抗原.在CAR-T疗法中,仿制性抗原受体的仿制性抗原受体这样一来,Ciltacabtagene的自动解读就变成了Ciltacabtagene.有效性有效性有效性.多发性骨髓瘤是多发性骨髓瘤的一种.复发/耐火性复发/耐火性在安全方面,安全是安全的.

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