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对抗肝纤维化的活性化合物研究的最新进展

Chuang Liu¹, Siqi Li¹, Changhao Zhang¹

¹Key Laboratory of Natural Resources of Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.

Current medicinal chemistry

|July 27, 2023

概括

研究人员审查了过去十年的抗肝纤维化化合物,重点是天然产品. 现有的合成化合物和结构-活性关系研究很少,这凸显了开发新抗纤维菌药物的差距.

科学领域:

药理学药理学是指药理学的学科.
肝病学肝病学是一种肝病学.
药用化学医学化学

背景情况:

慢性肝病经常发展为纤维化,肝硬化和肝癌.
肝纤维化是一种可逆的过程,对于预防肝癌至关重要.
目前,没有任何特定药物表现出强烈的肝脏抗纤维活性.

研究的目的:

审查过去十年开发的抗肝纤维化化合物的研究.
为设计和开发新型抗肝纤维化药物提供参考.
分析这些化合物的药理活性和结构-活性关系 (SAR).

主要方法:

化合物根据其化学结构被分类为:单环,合异环和非环.
文献综述侧重于具有抗纤维活性的天然产品和合成化合物.
强调的是药理活性和SAR.

主要成果:

审查发现了许多具有抗纤维性质的天然产品及其衍生物.
据报道,只有少数具有抗纤维性活性的合成化合物.
结构-活性关系 (SAR) 研究主要集中在天然产品上.

结论:

天然活性产品及其衍生物构成了大多数审查的化合物.
关于合成抗纤维素化合物的研究非常稀缺.
为了药物开发,需要对天然产品进行进一步的SAR研究.

关键词:

在HSC上,HSC是高质量的.肝脏纤维化肝脏纤维化这就是为什么SAR SAR SAR.慢性肝脏疾病慢性肝脏疾病肝硬化是肝硬化的一种疾病.原 I. 的结合物.

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