呼吸系统参数对机械通风患者排出的挥发性有机化合物的度的影响
Andrea Romano1, Matyas Fehervari1, Piers R Boshier1,2
1Department Surgery and Cancer, Imperial College, London, UK.
The Analyst
|July 27, 2023
概括
呼吸模式显著影响排出的挥发性有机化合物 (VOC). 呼吸速率主要影响异烯和,而潮体积仅影响异烯,指导优化呼吸分析.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 呼出的挥发性有机化合物 (VOC) 为生理状态提供了一个非侵入性的窗口.
- 方法和生理学的变化使呼吸中准确的VOC分析变得复杂.
- 调查呼吸模式对VOC资料的影响对于可靠的诊断至关重要.
研究的目的:
- 检查呼吸速率 (RR) 和潮体积 (TV) 的控制变化对排气中的VOC度的影响.
- 为了识别受呼吸模式变化影响的特定VOC.
- 为优化呼吸采样协议提供准则.
主要方法:
- 在线呼吸采样使用质子转移反应飞行时间质谱法 (PTR-ToF-MS).
- 对20名机械通风患者在受控RR和TV的分析.
- 量化19个选定的挥发性有机化合物,包括异烯,和.
主要成果:
- 呼吸速率显著影响了呼出的异烯和乙水平,显示了反向相关性.
- RR变化影响了C3-C7线性化物和酸.
- 异烯是唯一受潮体积变化影响的VOC;醇和其他化合物没有显著依赖RR.
结论:
- 呼吸模式,特别是呼吸速率,是影响呼出的VOC度的关键因素.
- 这些发现为在临床环境中改进呼吸采样技术提供了必要的数据.
- 优化方案是必要的,以准确的VOC分析在清醒的患者.
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