毒素菌感染和睡眠障碍之间的可能关联:系统性审查
Tooran Nayeri1, Shahabeddin Sarvi1, Ahmad Daryani1
1Toxoplasmosis Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Infectious disorders drug targets
|July 27, 2023
概括
根据系统性审查,T. gondii感染可能会增加患睡眠障碍的风险. 需要进一步的研究来证实T. gondii与睡眠障碍之间的联系.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 有限的研究存在于毒素菌和睡眠障碍之间的联系.
- 睡眠障碍与诸如自杀行为和事故等不良结果有关.
- 调查Toxoplasma gondii (T. gondii) 和睡眠障碍之间的关系至关重要.
研究的目的:
- 系统地审查和综合有关T. gondii感染和睡眠障碍之间的联系的现有文献.
- 评估T. gondii在患有睡眠障碍的人群中的患病率.
主要方法:
- 在2022年10月18日之前,对五个主要的英语数据库进行了系统搜索.
- 文章根据标题,摘要和全文进行了选,以确定相关性.
- 从8项选定的研究中提取和分析了数据 (4例-对照,4横截面).
主要成果:
- 该审查包括了926名睡眠障碍患者和1877名对照患者的病例对照研究数据.
- 对抗T. gondiiIgG抗体的血清阳性观察到22.89%的睡眠障碍患者和20.88%的对照人群.
- 在涉及2885名患有睡眠障碍的个体的横截面研究中,54.03%的测试结果对抗T. gondiiIgG抗体呈阳性.
结论:
- 建议T. gondii感染作为睡眠障碍的潜在危险因素.
- 目前的证据有限,有一些矛盾的发现.
- 需要进一步进行高质量的研究,才能确定T. gondii与睡眠障碍之间的明确联系.
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