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系统性炎症反应指数作为骨关节炎患者的新兴生物标志物:一个书籍测量和大样本回顾性调查
Qiao Zhou1, Jian Liu2, Ling Xin3
1Department of Rheumatism Immunity, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui; Department of Geriatrics, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui; and The First Clinical School of Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, China.
系统性炎症反应指数 (SIRI) 显示出作为评估骨关节炎疾病活动的非侵入性生物标志物具有前途. 在OA患者中,较高的SIRI水平与疾病严重程度和免疫标志物相关.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 骨关节炎 (OA) 是一种具有显著炎症成分的退行性关节疾病.
- 目前对OA疾病活动的评估依赖于临床症状和成像,需要更客观的生物标志物.
研究的目的:
- 评估全血炎症反应指数作为骨关节炎疾病活动的新生物标志物的实用性.
- 调查这些指数与OA的临床指标之间的相关性.
主要方法:
- 对关节炎和炎症文献进行图书统计分析.
- 从OA患者和健康对照组的临床数据的回顾性分析.
- 计算和相关性分析中性粒细胞/淋巴细胞计数 (NLR),血小板/淋巴细胞计数 (PLR),单细胞/淋巴细胞计数 (MLR) 和全身炎症反应指数 (SIRI).
- 接收器操作特征 (ROC) 曲线分析和后勤回归以确定切断值和疾病活动的预测能力.
主要成果:
- 这些关键词.
- 这是一种炎症炎症炎症炎症.
- 骨关节炎是一种关节炎.
- 疾病活动的疾病活动.
- 在文学中最为突出.
- 与健康对照组相比,OA患者的MLR,NLR,PLR和SIRI显著升高.
- SIRI和NLR有效地将OA与健康对照区分开来.
- SIRI,NLR,PLR和MLR与免疫标志物,VAS和SF-36得分相关联.
- SIRI,NLR和CRP预测了OA疾病活动,SIRI-CRP组合模型单独优于CRP.
结论:
- 系统性炎症反应指数 (SIRI) 是评估骨关节炎疾病活动的潜在非侵入性生物标志物.
- 在OA中,SIRI与已确定的炎症和疾病严重程度标志物有很强的相关性.
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