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甲状腺功能测试的变化和高甲状腺症中心血管疾病的发生率.

Nelli Suonsyrjä1, Iina Laihia1, Heini Huhtala2

  • 1Department of Internal Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Clinical endocrinology
|July 27, 2023
PubMed
概括
此摘要是机器生成的。

在抗甲状腺药物治疗期间,甲状腺功能测试的变化,特别是自由甲状腺素 (fT4) 水平,与心血管风险增加有关. 这种关联甚至在具有阳性铁红素受体抗体 (TRAbs) 的患者中仍然存在.

关键词:
格雷夫斯病 (Graves disease) 是一种疾病.抗甲状腺剂是一种抗甲状腺剂.心血管疾病心血管疾病甲状腺功能过强症 甲状腺功能过强症甲状腺功能测试测试甲状腺功能测试甲状腺激素 甲状腺激素甲状腺热素受体的受体

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科学领域:

  • 内分泌学 在内分泌学.
  • 心血管医学 心血管医学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 在抗甲状腺药物 (ATD) 治疗期间甲状腺功能测试 (TFT) 的变化在不良健康结果方面没有得到充分研究.
  • 在接受ATD治疗的甲状腺功能增强症患者中,心血管病率是一个重大问题.

研究的目的:

  • 调查治疗ATD的患者中TFT变异性和心血管发病率之间的关联.
  • 在ATD治疗期间确定特定的TFT参数和影响心血管风险的临床因素.

主要方法:

  • 对394名甲状腺过高患者进行了回顾性队列研究,这些患者接受了ATD治疗.
  • 计算后续TSH,ft4和ft3测量的变化系数 (CVs).
  • 后勤回归分析以评估TFT变异性,基线因素和与心血管疾病相关的医院访问之间的关联.

主要成果:

  • 增加fT4变异性 (fT4-CV) 是心血管疾病的独立风险因素 (OR:1.02,95% CI:1.01-1.04).
  • 年龄和男性性别也增加了心血管风险,而阳性TRAbs显示有保护作用 (OR:0.29,95%CI:0.14-0.61).
  • 即使在阳性TRAbs.患者中,fT4变异仍然与心血管疾病相关.

结论:

  • 在ATD治疗期间fT4水平的变化与心血管疾病发病率的增加有关.
  • fT4变异性与心血管风险之间的关联不管TRAb状态如何,都存在.