人类微生物组与癌症:一个诊断和治疗的视角
Shruthi Kandalai1,2, Huapeng Li3, Nan Zhang1,2
1Department of Radiation Oncology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Cancer biology & therapy
|July 27, 2023
概括
人类微生物组,包括唾液和便微生物,在癌症的发展,诊断和治疗反应中起着至关重要的作用. 了解这些微生物的作用是促进早期癌症检测和治疗的关键.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 新出现的证据将人类微生物组与各种疾病联系起来,尤其是癌症.
- 唾液,便和血液中的微生物群落正在被探索为诊断癌症的生物标志物.
- 瘤微环境和遥远的微生物组影响癌症的发展和进展.
研究的目的:
- 审查当前关于微生物对癌症影响的研究.
- 突出微生物在癌症诊断,发展,进展和治疗中的重要性.
- 强调需要更深入地了解改善临床护理的必要性.
主要方法:
- 对最近的研究进展进行文献综述.
- 对微生物对癌细胞和宿主免疫力的影响研究的分析.
- 检查微生物对癌症治疗疗效的影响.
主要成果:
- 微生物组与促进或限制癌症的发展和进展有关.
- 微生物显著影响癌症治疗的疗效,如辐射,化疗和免疫疗法.
- 唾液,便和循环的微生物DNA显示出作为癌症诊断生物标志物的潜力.
结论:
- 微生物在癌症中的参与是多方面的,影响了诊断,进展和治疗.
- 对癌症-微生物组轴的进一步研究对于早期检测和有效的治疗策略至关重要.
- 将微生物组的洞察力纳入临床实践可以增强癌症患者的护理.
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