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Updated: Jul 21, 2025

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强大的 (II) 基免疫细胞死亡诱导因子,由ROS介导的ERS和线粒体Ca2+过载触发

Lan-Shan Liao1,2, Yin Chen1, Cheng Hou1

  • 1State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.

Journal of medicinal chemistry
|July 27, 2023
PubMed
概括

两种基于的复合物,Zn1和Zn2,通过触发内质网膜应激和线粒体功能障碍,有效诱导免疫细胞死亡 (ICD). 这些复合物抑制瘤生长,改善小鼠的生存率,为癌症治疗提供了一种新的策略.

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