药物对狗甲状腺功能的影响:最新情况
Timothy A Bolton1, David L Panciera1
1Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
Journal of veterinary internal medicine
|July 27, 2023
概括
某些药物可以干扰狗的甲状腺激素水平,导致甲状腺功能测试不准确. 了解这些药物效应至关重要,以防止误诊的甲状腺功能低下症和避免不必要的治疗.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺功能测试对于诊断狗的甲状腺疾病至关重要.
- 药物可以显著影响甲状腺激素生理学,可能导致错误的测试结果.
- 此前关于这一主题的评论发表于20多年前.
研究的目的:
- 审查各种药物对犬类甲状腺功能测试的影响.
- 让兽医了解有关药物诱导的甲状腺激素水平变化的最新研究.
- 强调认识到这些影响的重要性,以防止误诊.
主要方法:
- 自上次综合性审查以来发表的研究的文献综述.
- 对特定药物的研究进行分析,包括阿米奥达龙,佐尼萨米德,吸入麻醉剂,克洛米普拉,三斯坦,托塞拉尼布,葡萄糖皮质激素,硫胺,巴比他尔和非类固醇抗炎药物.
- 综合与药物对甲状腺激素合成,分泌,分布和新陈代谢的影响相关的发现.
主要成果:
- 一些药物,包括amiodarone,zonisamide和吸入麻醉剂,已被证明可以改变狗的甲状腺功能测试.
- 其他评估药物,如克洛米胺,三斯坦和托塞拉尼布,也对甲状腺激素参数产生影响.
- 最近的研究强调了葡萄糖皮质类药物,硫胺类药物,巴比他和NSAIDs对甲状腺功能测试的影响.
结论:
- 意识到甲状腺功能测试中药物诱导的变化对于兽医的准确诊断至关重要.
- 如果不考虑这些药物效应,可能导致甲状腺功能低下症的错误诊断.
- 避免不必要的治疗需要充分了解药物如何影响甲状腺激素水平.
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