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在接受皮肤冠状动脉干预的ST升高心肌梗塞患者中,泛免疫炎症值和无反流之间的关联

Adil Bayramoğlu¹, Şıho Hidayet¹

¹Department of Cardiology, Inonu University, Malatya, Turkey.

Scandinavian journal of clinical and laboratory investigation

|July 27, 2023

概括

新型全免疫炎症值 (PIV) 有效预测ST升高心肌梗塞患者的无回流现象. 较高的PIV水平表明没有反流的风险更大,超过了全身免疫炎症指数 (SII).

科学领域:

心血管医学心血管医学
炎症和免疫学炎症和免疫学
生物标志物发现发现

背景情况:

没有回流是ST段升高心肌梗塞 (STEMI) 的关键并发症,与患者预后不佳有关.
一些炎症标志物,包括C反应蛋白和中性粒细胞与淋巴细胞的比率,与无反流现象有关.
系统性免疫炎症指数 (SII) 已经显示出预测价值,但新的指数需要调查.

研究的目的:

为了回顾评估泛免疫炎症值 (PIV) 与STEMI患者没有反流的发生之间的关系.
确定PIV是否可以作为无回流的独立预测因素.
为了比较PIV与SII的预测性表现,用于无回流.

主要方法:

一个回顾性分析包括1212名STEMI患者,其中145人没有经历反流.
多变量逻辑回归分析确定了无回流的独立预测因素.
接收器操作特征 (ROC) 曲线分析评估了PIV的诊断准确性,将其与SII进行比较.

主要成果:

PIV成为无回流 (OR: 1.025,p < 0.001) 的独立预测因素,除了基线喷射分数,支架长度,年龄和疼痛到PCI时间之外.
预测无反流的最佳PIV切线为≥889,显示了77.2%的灵敏度和77.5%的特异性 (AUC:0.828).
与SII相比,PIV对没有回流的预测能力明显更高 (p < 0.001).

结论:

升高的PIV是STEMI患者没有回流的独立预测因素.
与SII相比,PIV提供了与SII相比更好的无回流预测能力.
在STEMI中,PIV代表了一种有前途的新生物标志物,用于评估无回流风险.

关键词:

泛免疫性炎症的价值.ST-升高心肌梗塞的心脏病发作没有任何流动.通过皮肤进行冠状动脉干预.系统性免疫炎症指数

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