轨道质量作为扩散大B细胞淋巴瘤的呈现症状,导致自发瘤溶解综合征和快速多系统器官衰竭
Steven S Bae1, Steve Rasmussen1,2, David J A Plemel1
1Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
Orbit (Amsterdam, Netherlands)
|July 27, 2023
概括
这种病例突显出一种具有攻击性的扩散性大B细胞淋巴瘤 (DLBCL),其中轨道质量是由于巨大的瘤负担导致自发瘤溶解综合征的初始迹象.
科学领域:
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
- 病理学 病理学 病理学
背景情况:
- 轨道质量可以呈现出各种各样的病因.
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种侵略性的非霍奇金淋巴瘤.
- 瘤溶解综合征 (TLS) 是一种瘤紧急情况,其特征是瘤细胞快速死亡.
研究的目的:
- 报告DLBCL的不寻常和积极的表现.
- 突出轨道质量成为系统性疾病的初始表现的潜力.
- 为了强调在广泛的瘤负担的背景下识别自发TLS的重要性.
主要方法:
- 一个68岁的男性有轨道症状的病例报告.
- 诊断成像包括CT轨道.
- 轨道活检用于组织病理学检查.
- 对瘤负担和代谢障碍的系统评估.
主要成果:
- 患者呈现单边亡和视力丧失.
- 轨道活检证实非生殖中心扩散大B细胞淋巴瘤.
- 术后并发症包括心房和发烧,暗示TLS.
- 鉴定出了广泛的逆上皮质瘤负担.
- 快速进展的多系统器官衰竭导致患者死亡.
结论:
- 轨道DLBCL可以呈现出异常激烈的临床过程.
- 轨道质量可能是大型全身瘤负担和自发TLS的第一个指标.
- 在患有广泛淋巴瘤的患者中,迅速识别和管理TLS至关重要.
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